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Composition:
Freecof Syrup Each 5
ml syrup contains Dextromethorphan Hydrobromide BP 10 mg,
Pseudoephedrine Hydrochloridel BP 30 mg & Triprolidine
Hydrochloride BP 1.25 mg.
Pharmacology:
Freecof Syrup is the
combination of three active ingredients, Dextromethorphan
Hydrobromide, Pseudoephedrine Hydrochloride & Triprolidine
Hydrochloride. Dextromethorphan Hydrobromide has an antitussive
action. It controls coughs by spasm by depressing the medullary
cough centre. It is used to suppress dry or painful cough. It is
useful for clearing mucus, dust and other particles from the throat
and lungs. Pseudoephedrine Hydrochloride has a sympathomimetic
activity and is an effective upper respiratory decongestant. It acts
by stimulating alpha adrenergic receptors. In the lining of the nose
and sinuses, pseudoephedrine acts on receptors in the muscles of the
blood vessel walls, causing them to contract and therby decreases
blood flow to the lining of the nose and sinuses. By decreasing
blood flow, fluid congestion in the nose and sinuses is reduced.
Triprolidine is a sedating antihistamine which acts on histamine H1
receptors. It blocks the action of histamine, preventing dilatation
of blood vessels, reducing redness and swelling. Therefore, this
syrup is used to relieve the symptoms of colds and flu, such as
nasal congestion, cough and runny nose, where these are associated
with a dry cough.
Indications:
Freecof is indicated
for the symptomatic relief of upper respiratory tract disorders
accompanied by non-productive cough which are benefited by the
combination of a nasal decongestant, a histamine H1-receptor
antagonist, and an antitussive.
Dosage and
Administrations:
Adults : 2 tea-spoonfuls three times daily
Children
Over 12 years
: 2 tea-spoonfuls three times daily
6 to 12 years
: 1 tea-spoonful three times daily
2 to 5 years
: 1/2 tea-spoonful three times daily
6 months to 2 years
: 1/4 tea-spoonful three times daily or on advice of a
physician only.
Contraindications:
This syrup is
contraindicated in-patients with a known hypersensitivity to its
components. It is contraindicated in patients with severe
hypertension or severe coronary artery disease. Patients being
treated with monoamine oxidase inhibitors and within two weeks of
stopping such treatment, ephedrine and other sympathomimetic agents
as a hypertensive response may result. It is also contra-indicated
in asthmatic patients during an attack of asthma.
Side-Effects:
Central nervous
system depression or excitation may occur, drowsiness being reported
most frequently. Sleep disturbance and rarely, hallucinations have
been reported. Skin rashes with without irritation, tachycardia,
dryness of mouth, nose and throat have occasionally been reported.
Urinary retention has been reported occasionally in male patients in
which prostatic enlargement could be an important predisposing.
Precautions:
This combination may
cause drowsiness, and impair performance in tests of auditory
vigilance. Patients should not drive or operate machinery until they
have determined their own response. Although there are no objective
data, users of this syrup should avoid the concomitant use of
alcohol or other centrally acting sedatives. Although
pseudoephedrine has virtually no pressor effects in patients with
normal blood pressure, this syrup should be used with caution in
patients taking antihypertensive agents, tricyclic antidepressant,
other sympathomimetic agents such as decongestants, appetite
suppressants and amphetamine-like psychostimulants. As with other
sympathomimetic agents, caution should be exercised in patients with
hypertension, heart disease, diabetes, hyperthyroidism, elevated
intraocular pressure or prostatic enlargement.
Drug
Interactions:
Concomitant use of
this syrup with sympathomimetic agents, such as decongestants,
tricyclic antidepressants, appetite suppressants and
amphetamine-like psychostimulants, or with monoamine oxidase
inhibitors which interfere with the catabolism of sympathomimetic
amines, may occasionally cause a rise in blood pressure. Because of
its Pseudoephedrine Hydrochloride content, this syrup may partially
reverse the hypotensive action of drugs which interfere with
sympathetic activity including bretylium, bethanidine, guanethidine,
debrisoquine, methyldopa and beta-adrenergic blocking agents.
Use in Pregnancy
& Lactation:
Although
Pseudoephedrine Hydrochloride, Triprolidine Hydrochloride and
Dextromethorphan Hydrobromide have been in widespread use for many
years without apparent ill consequence, there are no specific data
on their use during pregnancy. Caution should therefore be exercised
by balancing the potential benefit of treatment to the mother
against any possible hazards to the developing fetus.
Storage:
Packing:
Freecof Syrup:
Bottle containing 100 ml syrup.
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