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Description:
Acyvir is a sterile eye ointment containing Acyclovir, which is active against herpes simplex virus.
Composition:
Acyvir Sterile Eye Ointment: Each gm ointment contains Acyclovir USP 30 mg.
Pharmacology:
Acyclovir is a synthetic purine nucleoside analogue, which acts against human herpes viruses. The enzyme thymidine kinase (TK) encoded by HSV, VZV and EBV converts acyclovir into acyclovir monophosphate, a nucleotide analogue, which is further converted to diphosphate and triphosphate by cellular enzymes. Acyclovir triphosphate interferes with DNA polymerase and inhibits viral DNA replication with resultant chain termination following its incorporation into the growing viral DNA chain.
Indications:
Acyvir sterile eye ointment is indicated for the treatment of Herpes Simplex infection.
Dosage and administrations:
Apply ointment into lower conjunctival sac five times daily at 4 hours interval; continue for minimum 3 days after healing.
Side-effects:
Transient mild stinging immediately following application may occur in a small proportion of patients. Local irritation and inflammation such as blepharitis and conjunctivitis have also been reported.
Contraindication:
It is contraindicated to the patients with known hypersensitivity to Acyclovir.
Pregnancy and lactation:
The use of Acyvir sterile eye ointment should be considered only when the potential benefits outweigh the possibility of unknown risk.
Storage:
Store between 15-250 C in a dry place. Protect from light. Keep out of the reach of children.
Packing:
Acyvir Eye Ointment: Each tube contains 5 g sterile eye ointment.
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