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Composition:
Each crackable & chewable (Alfa-E) tablet contains Vitamin E BP(dl-alpha Tocopherol Acetate) 200 mg.
Description:
Alfa-E(Vitamin E) is a crackable and chewable tablet with pleasant taste. Alfa-E(Vitamin E) protects cellular constituents from oxidation and prevents the formation of toxic oxidation products.
Therapeutic Use:
Hemolytic anemia due to Vitamin E deficiency (in premature infants) intermittent claudication.
Pharmacology:
The antioxidant properties of vitamin E ameliorate free radical damage to biological membranes. Vitamin E protects polyunsaturated fatty acids within membrane phospholipids and within circulating lipoproteins.
Indications:
As a dietary supplement and for prophylactic use: To meet raised requirements (e.g. pregnancy and lactation period, high dietary intake of polyunsaturated fatty acids etc. For prevention of Vitamin E deficiency due to malabsorption syndromes caused by pancreatic, hepatobiliary and gastro-intestinal disorders. For the prevention of several degenerative consequences of oxidation of LDL like atherosclerosis, coronary heart diseases. To delay the onset of age related health problems.
For reduction of nitrate tolerance in patients with angina & myocardial infarction taking continuous Nitrate therapy. As a supportive therapy in Dupuytrens' contracture, male infertility.
Dosage & administration:
Dosage varies according to individuals' need. The following dosages are recommended in different indications:
| Indication |
Dosage |
| As a supplement or prophylactic use |
100-300 mg daily |
| Increased requirements |
| Malabsorptoin syndromes |
100-300 mg daily |
| Coronary heart disease |
200-300 mg daily |
| As a supportive therapy |
| Dupuytren's contracture |
| Male infertility |
100-200 mg daily |
| Hemolytic anemia in premature infants |
100-200 per kg body weight |
| Intermittent claudication |
300-600 mg daily |
Side-effects:
Nausea, flatulence or diarrhoea may occur. High dose Vitamin E (generally more than 400 mg daily) has been associated with a variety of minor side effects, including hypertension, fatigue, diarrhoea, myopathy and thrombophlebitis.
Pregnancy and Lactation:
Vitamin E may be used in pregnancy in the normally recommended dose but the safety of high dose therapy has not been established. There appears to be no contraindication to breast feeding by mothers taking the normally recommended dose.
Contraindication:
There is no absolute contraindication.
Precaution:
Vitamin E may enhance the anticoagulant activity of anticoagulant drugs. Caution is advised in premature infants with high dose Vitamin E supplementation, because of reported risk of necrotizing enterocilitis.
Use in pregnancy and Lactation:
Vitamin E may be used in pregnancy in the normally recommended dose but the safety of high dose therapy has not been established. There appears to be no contraindication to breast feeding by mothers taking the normally recommended dose.
Drug Interaction:
High doses of Vitamin E can impair intestinal absorption of Vitamin A & K.
Overdose:
No cases of this kind appear to have been reported.
Packing:
Bottle containing 15 tablets.
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