Composition:

Beclovan Tablet: Each tablet contains Baclofen BP 10 mg.

Pharmacology:

Beclovan is an effective muscle relaxant and antispastic agent with a spinal site of action. It exerts its action by inhibiting both monosynaptic and polysynaptic transmission in the spinal cord by stimulating GABAB receptors.

Indications:

Beclovan is indicated for the alleviation of spasticity resulting from multiple sclerosis particularly for the relief of flexor spasm and concomitant pain, clonus and muscular rigidity, spinal cord diseases, muscle spasm of cerebral origin especially infantile cerebral palsy, stroke or neoplastic or degenerative brain diseases. It may be of some value in patients with trigeminal neuralgia, tardive dyskinesia, cluster headache & tension type headache.

Dosage & administration:

Muscle relaxant & spasticity: For adults: Initially 5 mg three times daily for 3 days; then 10 mg three times daily for 3 days, 15 mg three times daily for 3 days and 20 mg three times daily. Additional increases in dose may be required but should not exceed 20 mg four times daily. Maximum daily dose for spasticity should not exceed 260 mg.

For children (treatment of spasticity): Initially 1.0-1.5 mg/kg/day in 3 divided doses. Titrate to a maximum of 40 mg/day if less than 8 years of age and to a maximum of 80 mg/day if more than 8 years of age.

Trigeminal neuralgia: 50-60 mg daily in divided doses.

Tardive dyskinesia: 40 mg daily in divided doses combination with neuroleptics.

Contraindications:

Beclovan is contraindicated in patients who are hypersensitive to any component of this preparation.

Side effects:

Beclovan may cause drowsiness, weakness, dizziness, headache, seizures, nausea, vomiting, low blood pressure, constipation etc.

Warning:

Hallucinations and seizures may occur on abrupt withdrawal of baclofen. Therefore, except for serious adverse reactions, the dose should be reduced slowly when the drug is discontinued.

High risk group:

Pregnancy: There are no adequate and well-controlled studies in pregnant women. So, baclofen should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Lactation: It is not known whether this drug is excreted in human milk. Caution should be exercised when baclofen is administered to lactating mother.

Elderly: Elderly patients are more likely to have decreased renal function. Thus care should be taken in dose selection and it may be useful to monitor renal function. Moreover, it may be necessary to reduce the dosage in patients with impaired renal function.

Drug interactions:

The central nervous system depressant effects of baclofen may be additive to those of alcohol and other CNS depressants.

Packing:

Beclovan Tablet: Each box contains 3X10's tablets in blister pack.