| CLINEX
LOTION
Clindamycin
Description:
Clinex lotion, a topical antibiotic contains
Clindamycin Phosphate, which has anti-acne and antibacterial
activity. It binds to the 50S subunit of the bacterial ribosome
and inhibits the early stage of protein synthesis. It is active
against most aerobic gram-positive bacteria as well as has good
activity against anaerobic bacteria.
Composition:
Each ml lotion contains Clindamycin Phosphate
USP equivalent to Clindamycin 10 mg
Pharmacology:
Clindamycin Phosphate rapidly hydrolizes to active
clindamycin in vivo by tissue phosphatase. Clindamycin acts
as anti-acne agent due to its antibacterial activity. Topical
Clindamycin lotion is thought to reduce free fatty acid concentration
on the skin and to suppress the growth of Propionibacterium
acnes (Corynebacterium acnes), an anaerobe found in sebaceous
glands and follicles.
Indications:
Acne vulgaris: Clinex lotion is indicated
in the treatment of acne vulgaris, which are characterized by
inflammatory lesions such as papules and pustules.
Skin infection: Clinex lotion is used
in the topical treatment of erythrasma caused by Corynebacterium
minutissimum; rosacea, periorificial dermatitis, folliculitis,
stasis, chronic lymphaedema and familial pemphigus.
Clinex lotion is also used in the treatment
of dermal ulcers.
Dosage and Direction for use:
Cleanse the face or affected area gently with
warm water or soap as recommended by the physician. After the
skin is dried, apply a thin film of Clinex lotion to
the affected areas twice daily, in the morning and in the evening.
Do not wash within three hours after using lotion. The treatment
period is usually 6 weeks or advised by the physician.
Side-effects:
Serious side effects are not likely to occur.
Some rare side effects are dryness, erythema, burning, peeling,
oily skin, etching, diarrhoea, colitis, GI disturbances.
Contraindications:
Patients who have hypersensitivity to Clindamycin
or Lincomycin, history of regional enteritis or ulceration colitis
or antibiotic associated colitis.
Precautions:
Pregnancy: There is no adequate study on safety
of Clindamycin in pregnant women.
Lactation: It is not known whether the agent
is excreted in human milk, so caution should be exercised when
administering to a nursing mother.
Children: Safety and effectiveness in children
under 12 years have not been established.
Drug Interaction:
Clindamycin should be used with caution in patients
receiving neuromuscular agents and erythromycin.
Patient Information:
-
This medication to be used as directed by
physician. It is for external use only.
-
Avoid contact with eyes, nose, mouth, and
other mucous membranes.
-
Wash hands immediately after use.
-
Patient should report any signs of local
adverse reactions or abdominal pain or diarrhoea to the
physician.
Storage:
Packing:
Bottle containing 25 ml lotion. |
