Composition:

Clinex Plus Gel: Each gram gel contains Clindamycin Phosphate USP 12 mg and Tretinoin USP 0.25 mg.

Pharmacology:

Clinex Plus is a topical gel, which is a combination of Clindamycin and Tretinoin. Clindamycin is an antibiotic that inhibits bacterial protein synthesis. It has been found effective against Propionibacterium acnes. Tretinoin is a retinoid that has been shown to reduce microcomedo formation. It also reduces the cohesiveness and increases the turnover of follicular epithelial cells, causing extrusion of the comedones.

Indications:

Clinex Plus Gel is indicated for the topical treatment of acne.

Dosage & administration:

Apply thin film to clean, dry face once daily at bedtime.

Directions of use:

• Wash the face gently with a soap and warm water & dry the face.
• Apply the gel smoothly with finger tips.
• Use soap as recommended by the physician.

Contraindications:

Patients who have hypersensitivity to Clindamycin and Tretinoin, history of regional enteritis, ulcerative colitis or antibiotic-associated colitis.

Side-effects:

Erythema, itching, burning, nasopharyngitis, throat pain, dry skin, cough, sinusitis, diarrhea & colitis may occur.

High risk group:

Lactation: There are no well-controlled trials in pregnant women treated with Clindamycin and Tretinoin gel. It should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Lactation: It is not known whether Clindamycin and/or Tretinoin are excreted in human milk. Caution should be exercised when Clindamycin and Tretinoin gel is administered to a nursing woman.

Pediatric: Safety and effectiveness of Clindamycin and Tretinoin gel in pediatric patients under the age of 12 have not been established.

Drug interactions:

Clindamycin & Tretinoin should be used with caution in patients receiving neuromuscular agents, erythromycin, tetracyclines, quinolone and other topical products (eg. Alcohol, drying agent).

Packing:

Clinex Plus Gel: Two types of tube each contains 15g and 20g gel.