| ERDON
PLUS
Diclofenac Sodium + Lidocaine
Description:
Diclofenac is a potent non-steroid anti-inflammatory
drug (NASID) with analgesic and anti-pyretic properties. It
has also some uricosuric effect. Diclofenac inhibits cyclooxygenase
activity with a reduction of the tissue production of prostaglandin.
Lidocaine (Lignocaine) is effectively absorbed from mucous membranes
and is used combined with diclofenac as a useful surface anesthetic
in concentrations of 2% to 4% to reduce muscular pain at the
site of injection.
Composition:
Each 2 ml ampoule of aqueous injection contains
Diclofenac Sodium BP 75 mg and Lidocaine BP 20 mg.
Indications:
Rheumatology: Inflammatory and degenerative forms
of rheumatism, chronic involutive, polyarthritis. Surgery and
Traumatology: Sprain, bruises, dislocations, fractures, soft-tissue
injuries, surgical interventions. Obstetrics and Gynecology:
Primary dysmenorrhoea, episitomy, adnexitis, endometritis, parametritis,
salpingitis, and mastitis. Otorhinolaryngology: As pre–operative
medication for the prevention of pain, inflammation, and swelling.
Dentistry: Post-operative and post-traumatic pain, inflammation,
and swelling.
Other indications: For the prevention of pain
and treatment of inflammation swelling of patients operated
in the urogenital tract, renal and biliarycolic.
Dosage and administration:
Erdon-plus ampoules contain aqueous solutions
of PH 7.8-8.0, containing diclofenac sodium 75 mg & Lidocaine
hydrochloride 20mg in 2 ml ampoule and is intended for intramuscular
injection or intravenous infusion. For intravenous infusion
dilute immediately before use. Recommended dosage-
In adults:
For post-operative case: Diclofenac sodium 75
mg & Lidocaine hydrochloride 20 mg/2 ml once daily (in severe
cases twice daily) deep intramuscular injection. Renal colic:
Diclofenac sodium 75 mg & Lidocaine hydrochloride 20 mg/2
ml once daily by deep intramuscular injection. Further Diclofenac
sodium 75 mg & Lidocaine hydrochloride 20 mg/2 ml after
30 minutes should be given. The maximum daily dosage of diclofenac
sodium & Lidocaine HCl is 150 mg.
In children:
For juvenile chronic arthritis: 1-3 mg of diclofenac
contained Lidocaine HCl / Kg body weight in divided doses.
Contraindications:
Peptic ulcer, hypersensitivity to diclofenac
like other non-steroid anti-inflammatory agents, Erdon Plus
injection is also contra-indicated in asthmatic patient in whom
attack with asthma, urticaria or acute rhinitis.
Precaution:
In the rare instances where peptic ulceration
or gastrointestinal bleeding occurs in patients under treatment
with Erdon-Plus. In patients with advanced age should
be kept under close surveillance. Patients receiving long-term
anti-steroid therapy should be monitored as a precautionary
measure (renal or hepatic function and blood counts).
Using in pregnancy and lactation:
During pregnancy Erdon Plus should be
employed only for compelling reasons. The lowest effective dose
should be used. These types of drugs are not recommended during
the last trimester of pregnancy. Very insignificant quantity
of diclofenac may be detected in breast milk but no undesirable
effects on the infant to be expected.
Side-effects:
Adverse effects of diclofenac are mild, rare
and transient. It is generally well tolerated. At the starting
of the treatment, however, patients may sometimes complain of
epigastric pain, eructation, nausea and Diarrhoea, or the dizziness
or headache. These effects are usually of mild in nature. Peripheral
edema and skin reactions, such rash and eczema have also been
encountered.
Storage:
Packing:
Erdon Plus Injection: Each box containing
4 x 3's in blister pack.
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