| FUSIDATE H Cream
Fusidic
Acid
Hydrocortisone Acetate
Description:
Fusidate-H cream
combines the potent topical antibacterial action of Fusidic
Acid with the anti-inflammatory & anti-pruritic effect of
Hydrocortisone Acetate. When applied topically, Fusidic Acid
is effective against Staphylococci, Streptococci, Corynebacteria,
Neisseria and certain Clostridia & Bacteroides.
Composition:
Each gram cream
contains Fusidic Acid BP 20 mg & Hydrocortisone Acetate
BP 10 mg.
Pharmacology:
Fusidic Acid is
an antimicrobial agent that acts as an inhibitor of protein
synthesis in the microorganism. It interferes with translocation
step by stabillizing the ribosome-guanosine diphosphate
elongation factor G-complex. This prevents binding of aminoacyl
t-RNA to the ribosome and thereafter stops transfer of additional
amino acids to the growing polypeptide.
Hydrocortisone
is, in humans, the principal naturally occurring glucocorticosteroid.
In pharmaceutical doses its main action is to reduce the response
of the skin to injury (i.e. anti-inflammatory). It also has
immunosuppressant & anti-mitotic actions.
Indications:
1. Primary irritant
dermatitis.
2. Contact allergic
dermatitis.
3. Eczema-atopic;
infantile; discoid; stasis.
4. Seborrhoeic
dermatitis.
5. Lichen simplex
& pruritus ani.
6. Flexural psoriasis.
Dosage &
administration:
Fusidate-H
cream should be applied in a thin smear to the rash 2-3 times
daily, massaged gently into the skin generally for a period
of 7 days to the affected area. As the skin rash improves, the
frequency of application should be gradually reduced. As topical
steroids exhibit tachyphylaxis, it may be better to omit therapy
for several days every fortnight.
Side-effects:
Hypersensitivity
has rarely encountered. As with other topical steroids, prolonged
& intensive treatment may cause local atrophic changes of
the skin such as striae, thinning & dilatation of the superficial
blood vessels, particularly when occlusive dressing is used
or when skin folds are involved. Systemic absorption, sufficient
to produce adrenal suppression, can occur with prolonged or
extensive use, especially when napkin is used. Infants and children
are particularly at risk. It should be exercised if a topical
steroid is used near the eye. Glaucoma might be the result if
the preparation enters the eye.
Contraindications:
1. Known hypersensitivity
to any of the components.
2. Severe hepatic
failure.
3. Infection- bacterial,
viral, fungal, skin infection.
4. Ulcers (delayed
wound healing).
5. Infants under
1 year.
Use in Pregnancy
& Lactation:
Fusidic Acid &
Hydrocortisone should not be used in pregnancy. Both of them
have been detected in the breast milk, so nursing mothers are
advised not to use the drug.
Drug Interactions:
Fusidic Acid may
inhibit the metabolism of drugs which undergo extensive bio-transformation
in the liver, but no evidence for this is available. Food may
delay absorption of Fusidic Acid. No hazardous drug interactions
are reported with topical hydrocortisone.
Storage:
Packing:
Collapsible aluminium
tube containing 10 g cream. |
