| GIRAN
Candesartan Cilexetil
Description:
Candesartan Cilexetil is an ester prodrug that
is hydrolysed in the body to the active form Candesartan during
absorption from the gastro-intestinal tract. Candesartan is
angiotensin II receptor (type AT1) antagonist. Candesartan blocks
the vasoconstrictor and aldosterone-secreting effects of angiotensin
II by selectively blocking the binding of angiotensin II to
the AT1 receptor in many tissues (eg, vascular smooth muscle,
adrenal gland).
Composition:
Giran-8 Tablet: Each tablet contains Candesartan
Cilexetil INN 8 mg.
Giran-16 Tablet: Each tablet contains
Candesartan Cilexetil INN 16 mg.
Indications:
Treatment of hypertension alone or in combination
with other antihypertensive agents.
Dosage & Administration:
Initially 4 mg (2 mg in hepatic and renal impairment)
once daily adjusted according to response; usual maintenance
dose 8 mg once daily; max. 16 mg once daily.
Contraindications:
Hypersensitivity to any component of this product.
Pregnancy, breast-feeding, cholestasis.
Drug Interactions:
No significant drug interactions have been reported
in studies of Candesartan Cilexetil given with other drugs such
as glyburide, nifedipine, digoxin, warfarin, hydrochlorothiazide
and oral contraceptives in healthy volunteers. Because candesartan
is not metabolised by the cytochrome P-450 system and has no
effects on P-450 enzymes, interactions with drugs that inhibit,
or are metabolised by, those enzymes could not be expected.
Side-effects:
Side-effects are usually mild. Symptomatic hypotension
may occur, particularly in patients with intravascular volume
depletion (e.g. those taking high dose diuretics). Also upper
respiratory tract and influenza like symptoms including rhinitis
and pharyngitis; abdominal pain, back pain, arthralgia, myalgia,
nausea, headache, dizziness, peripheral oedema, rash also reported;
rarely urticaria, pruritus, blood disorders reported.
Precautions:
Candesartan should be used with caution in renal
artery stenosis, aortic or mitral valve stenosis and in obstructive
hypertropic cardiomyopathy. Monitoring of plasma-potassium concentration
is advised, particularly in the elderly and in patients with
renal impairment; lower initial doses may be appropriate in
these patients.
Use in Pregnancy and Lactation:
When pregnancy is detected, Candesartan Cilexetil
should be discontinued as soon as possible. It should be used
in lactation.
Paediatric use:
Safety and effectiveness in paediatric patients
have not been established.
Packing:
Giran-8 Tablet: Each box contains 3×10’s
tablets in blister pack.
Giran-16 Tablet: Each box contains 3×10’s
tablets in blister pack. |
