| LOMEFLOX
Lomefloxacin
Description:
Lomeflox
(Lomefloxacin) is a synthetic fluoroquinolone anti-infective
agent. It is active against a wide range of gram-negative and
gram-positive organisms.
Presentation:
Each
film coated tablet contains Lomefloxacin HCl equivalent to Lomefloxacin
INN 400 mg.
Indications:
a)
Treatment:
•
Uncomplicated urinary tract infection.
•
Complicated including recurrent and pyelonephritis, urinary
tract infections.
•
Acute exacerbation of chronic bronchitis.
•
Skin and skin structure infection.
b)
Prevention/Prophylaxis:
Lomeflox
(Lomefloxacin) is indicated preperatively to prevent postoperative
urinary tract infections in patients undergoing transurethral
surgical procedures.
Dosage
& Administration:
Lomeflox
(Lomefloxacin) is recommended at the doses and for
the durations of treatment listed in the following table, and
may be taken with or without food at bed time.
| |
Disorder |
Dose |
Duration or treatment |
| 1. |
Typhoid fever |
400 mg once daily or 200 mg b.i.d | 10-14 days |
| 2. |
Uncomplicated urinary tract infection |
400 mg once dailyor 200 mg b.i.d | 3 days |
| |
Complicated urinary tract infection |
400 mg once daily or 200 mg b.i.d
| 10-14 days |
| |
Diarrhoea due to bacterial origin |
400 mg once daily or 200 mg b.i.d
|
5-7 days |
| |
Acute exacerbation of chronic bronchitis |
400 mg once daily |
7-10 days |
| |
Skin and skin structure infections |
400 mg once daily |
10-14 days |
| |
Prophylaxis of urinary tract infection following
surgery |
400 mg |
Single dose 2-6 hours prior to transurethral
surgery |
Contraindications:
Lomeflox
(Lomefloxacin) is contraindicated in patients with a history
of hypersensitivity to Lomeflox (Lomefloxacin) or to
other quinolones. Lomeflox (Lomefloxacin), like other
drugs in its class, cause arthropathy in juvenile animals. Therefore,
its use in children, growing adolescents, and pregnant women
is not recommended.
Precautions
& Warnings:
Alterations
of the dosage regimen is recommended for patients with impairment
of renal function (Ccr<40ml/min/1.73 sq.m). Avoid exposure
to excessive sunlight or artificial UV light. Phototoxicity
reaction may occur if undue exposure occurs. Safety and efficacy
of Lomeflox (Lomefloxacin) has not been established in
children, pregnant and lactating women.
Drug
Interaction:
Does
not alter theophylline clearance and concentration. No change
of caffeine is reported. Sucralfate and antacid containing magnesium
and aluminium interfere with its bioavailability. Enhances effects
of warfarin. Probenecid slows renal elimination of Lomeflox
(Lomefloxacin) Side effects:
Nausea,
headache, photosensitivity, dizziness, diarrhoea, dry mouth,
fatigue, convulsions, CNS stimulation which may lead to tremors,
restlessness, light headedness, confusion & hallucinations
and pseudomembranous colitis.
Storage:
Store
between 150 & 300 C. Protect from
light.
Packing:
Box
containing 2 x 10's in Alu-Alu blister pack. |
