NAPRO

Naproxen

Description:

Napro is a preparation of naproxen, which is a non-steroidal anti-inflammatory agent. The drug exhibits anti-inflammatory, analgesic and antipyretic activity. Naproxen is an inhibitor of prostaglandin synthesis.

Composition:

Napro Tablet: Each tablet contains 250 mg Naproxen.

Napro-500 Tablet: Each Tablet contains 500 mg Naproxen.

Indications:

Napro is indicated in the active stages of inflammatory rheumatic diseases, rheumatoid arthritis, ankylosing spondylitis, in soft tissue rheumatism & musculoskeletal disorders, acute gout, dysmenorrhoea.

Dosage & Administration:

In rheumatic disorders, the usual initial dose of naproxen is 250 mg twice daily adjusted to 500 mg to 1000 mg daily in 2 divided doses. A dose of 10 mg/kg body weight daily in 2 divided doses is used for children over 5 years of age with juvenile arthritis. In acute gout an initial dose of 750 mg followed by 250 mg every 8 hours has been suggested. In dysmenorrhoea, 500 mg may be given initially followed by 250 mg in every 6-8 hours.

Contra-indications:

History of asthma attacks or urticaria triggered by acetylsalicylic acid or other prostaglandin synthesis inhibitors.

Precautions:

Use of Naproxen should be avoided in patients with gastrointestinal disorders and gastro-duodenal ulcer. In case of severe hepatic or renal damage or disturbance of cardiac function a close medical surveillance is indicated. Blood counts including platelet counts, as well as monitoring of hepatic and renal functions are recommended, particularly in patients under long-term therapy.

Unwanted effects:

Naproxen is generally well tolerated, but occasionally patient may complain gastric  discomfort, nausea & dizziness. In exceptional cases, very sensitive patients may suffer from gastro-intestinal bleeding, skin rashes, thrombocytopenia.

Drug Interactions:

Antacid: The absorption of naproxen can be altered by antacids.

Aspirin: Plasma concentration of Naproxen can be reduced when aspirin is given concomitantly, this appeared to be due to increased excretion of naproxen.

Diuretics: Naproxen diminish the effect of furosemide.

Probenecid: It increase the plasma concentration of naproxen.

Overdosage:

Significant overdosage of the drug may be characterized by drowsiness, heart-burn, indigestion, nausea or vomiting. It is not known what dose of the drug would be life threatening.

Pharmaceutical precautions:

Protect from light & store in a cool, dry place. Keep out of the reach of children.

Packing:

Box containing 5 x 10's tablets of 250 mg in blister pack.

Box containing 3 x 10's/5 x 10's tablets of 500 mg in blister pack.