OPTIMOX
Moxifloxacin
Description:
Optimox (Moxifloxacin) is a synthetic
broad-spectrum antibacterial agent for oral administration.
Optimox (Moxifloxacin) has in vitro activity against
wide range of Gram-positive and Gram-negative microorganisms.
The bacterial action of Optimox (Moxifloxacin) results
from inhibition of the topoisomerase II (DNA gyrase) and topoisomerase
IV required for bacterial DNA replication, transcription,
repair, and recombination. US FDA approved Moxifloxacin for
the treatment of acute exacerbations of chronic bronchitis,
acute sinusitis, and pneumonia.
Composition:
Each film-coated tablet contains Moxifloxacin
HCl INN equivalent to Moxifloxacin 400 mg.
Indications:
Moxifloxacin is indicated for the treatment
of infections caused by susceptible microorganisms in the
conditions listed below in adults:
-
Acute bacterial
sinusitis
-
Acute bacterial
exacerbation of chronic bronchitis
-
Mild to moderate
community acquired pneumonia
-
Uncomplicated
skin and skin structure infections
Dosage & administration:
The usual dose of Optimox (Moxifloxacin)
tablet is 400 mg once a day. The specific dosage and duration
of Optimox in specific indications are as follows:
|
Infections |
Dose |
Duration |
|
Acute bacterial sinusitis |
400
mg once a day |
10
days |
|
Acute bacterial exacerbations of chronic bronchitis |
400
mg once a day |
5
days |
|
Community–acquired pneumonia |
400
mg once a day |
10
days |
|
Uncomplicated skin and skin structure infections |
400
mg once a day |
7
days |
Contraindications:
Optimox (Moxifloxacin) is contraindicated
in the patients with known hypersensitivity to Moxifloxacin,
or any members of the quinolone class of antimicrobial agents.
Side-effects:
Most side effects reported with Moxifloxacin
treatment are mild to moderate in severity and required no
treatment. Side effects include nausea, vomiting, diarrhea,
dizziness, headache, abdominal pain, anorexia, anxiety, constipation,
dry mouth, leukopenia, eosinophilia, myalgia, confusion, vertigo,
insomnia, hallucination, palpitation, hypotension, hypertension,
tachycardia, etc.
Precautions:
Moxifloxacin has been shown to prolong the
QT interval of the ECG in some patients. It should be avoided
in patients with known prolongation of QT interval, patients
with uncorrected hypokalemia, and patients receiving Class
IA (e.g. quinidine), or Class III (e.g. Amidarone), antiarrythmic
agents, due to lack of clinical experience with the drug in
these patients populations.
Use in Pregnancy:
There are no adequate and well-controlled studies
in pregnant women. So, Moxifloxacin should only be given during
pregnancy if the potential benefit justifies the potential
risk to the fetus.
Use in Lactation:
Moxifloxacin may be excreted in the human breast
milk. Because of the potential for serious adverse in reaction
infants nursing from mothers taking Moxifloxacin, a decision
should be made whether to discontinue nursing or to discontinue
the drug, taking into account the importance of the drug to
the mother.
Paediatric Use:
Safety and effectiveness in pediatric patients
and adolescents less than 18 years of age have not been established.
Drug Interaction:
Antacids containing aluminum, magnesium, or
calcium, sucralfate, metal cations such as iron, multivitamins
containing iron or zinc preparations containing divalent &
trivalent cations, etc. may interfere with the absorption
of quinolones, resulting in lower systemic concentration than
desired. So, Moxifloxacin should be given at least 4 hours
before or 8 hours after taking any of such drugs.
No clinically significant drug interactions
between theophylline, warfarin, digoxin, or glyburide have
been observed with Moxifloxacin.
Storage:
Packing:
Optimox Tablet: Box containing 1 x 10’s
tablets in Alu-Alu blister pack.
