OPTIMYCIN

Gentamicin Injection

Description:

Optimycin Injection contains Gentamicin Sulphate, which is an aminoglycoside antibiotic. Gentamicin has proven bactericidal action against an extremely broad spectrum of gram-positive and gram–negative pathogens including E. coli, Klebsiella, Proteus, Pseudomonas aeruginosa and penicillin resistant strains of Staph. aureus. The exact mechanism of action is unknown but in common with other aminoglycoside antibiotics it appears to interfere with protein synthesis of bacterial cell.

Composition:

Optimycin 20 Injection: Each 2 ml ampoule contains Gentamicin Sulphate USP equivalent to Gentamicin 20 mg  

Optimycin 80 Injection: Each 2 ml ampoule contains Gentamicin Sulphate USP equivalent to Gentamicin 80 mg  

Indications:

Optimycin Injection is indicated in septicemia and neonatal sepsis, meningitis and other CNS infections; chest infections; biliary tract infections; acute pyelonephritis or prostatitis; endocarditis caused by Streptococci viridans or faecalis (with a penicillin); wound infection & burns, gonorrhea and persistent stains of both Gram-negative & Gram-positive organisms. It is also indicated in pre -& post-operative infections, bone & soft tissue infections.

Dosage and administration:

Optimycin Injection is given by intramuscularly or by intravenous injection over at least 3 minutes or by intravenous infusion.

Adult:  

2-5 mg/Kg daily in divided doses every 8 hours, if renal function is normal. Patients with impaired renal function the interval between doses should be increased to 12 hours when the creatinine clearance is 30-70 ml/min, 24 hours for 10-30 ml/min, 48 hours for 5-10 ml/min or may be given as directed by the physician.

Streptococcal or enterococcal endocarditis in combination with other drugs, 80 mg twice daily.

Child:

Up to 2 weeks: 3 mg / Kg every 12 hours, 2 weeks-12 years: 2 mg / Kg every 8 hours.

Contraindications:

Optimycin Injection is contraindicated to patients hypersensitive to Gentamicin. It is also contraindicated in myasthenia gravis.

Side-effects:

Vestibular and auditory damage, nephrotoxicity; rarely, hypomagnesaemia on prolonged therapy, antibiotic associated colitis; also reported, nausea, vomiting, rash etc.

Precautions & Warnings:

Renal impairment, early pregnancy, premature infants & elderly, myasthenia gravis, Parkinsonism. 

Use in Pregnancy:

Where possible aminoglycosides should be avoided in pregnancy as they cross the placenta and can cause fetal eighth nerve damage.

Drug Interactions:

Potent diuretics. Increases toxicity with nephrotoxic agents. Prolongs effects of neuromuscular blockers.

Admixture Incompatibility:

Do not physically premix Gentamicin with other drugs; administer separately in accordance with route and dosage schedule.

Storage:

• Store between 2-30º C temperature.

• Refrigeration is not required.

• Keep out of the reach of the children.

Packing:

Optimycin 20 mg Injection: Box containing 5 x 3’s ampoules in blister pack.

Optimycin 80 mg Injection: Box containing 5 x 2’s ampoules in blister pack.