Our Products

Product details Products Home
Lomeflox Eye Drops

Lomeflox Eye Drops

Lomefloxacin

Lomefloxacin, a difluorioniated quinolone derivative, is a bacterial gyrase inhibitor, effective against gram positive and gram negative bacteria. Lomefloxacin interferes with bacterial DNA related processes like initiation, elongation and termination phases of replication, transcription, DNA repair, recombination, transposition, supercoling and relaxation of DNA, resulting in a rapid killing of sensitive bacteria.

Cross-resistance has only been reported with other quinolones, but not with any other group of antibiotics. No clinical studies are available about the efficacy in case infections with chlamydia.

Product Details

Presentation

Lomeflox Sterile Eye Drops: Each ml contains Lomefloxacin Hydrochloride INN equivalent to Lomefloxacin 3 mg.

Pharmacology

Lomefloxacin, a difluorioniated quinolone derivative, is a bacterial gyrase inhibitor, effective against gram positive and gram negative bacteria. Lomefloxacin interferes with bacterial DNA related processes like initiation, elongation and termination phases of replication, transcription, DNA repair, recombination, transposition, supercoling and relaxation of DNA, resulting in a rapid killing of sensitive bacteria.

Cross-resistance has only been reported with other quinolones, but not with any other group of antibiotics. No clinical studies are available about the efficacy in case infections with chlamydia.

Indication

Bacterial infections, including conjunctivitis, keratitis, corneal ulcer, blepharitis and blepharo-conjunctivitis which are due to Lomefloxacin susceptible microorganisms.

Dosage & Administration

Adults and children (above 1 year of age): Instill 2-3 times daily 1 drop into the lower conjunctival sac. At the beginning of the treatment application should be more frequent, apply 5 drops within 20 minutes or 1 drop every hour during 6-10 hours. Duration of the treatment: 7 to 9 days.

Contraindications

Hypersensitivity to the active ingredient, to excipients, or to quinolones. No adverse effects were noted in children.

Warning & Precautions

Long term treatment with antibiotic may enhance development of secondary fungal infections or may support growth of non-susceptible bacteria. Some isolated cases of phototoxicity have been reported after systemic but not after topical ophthalmic use of Lomefloxacin. Nevertheless, during treatment with Lomefloxacin intensive exposure to sunlight or UV-radiation should be avoided.

Side effects

Slight and transient burning immediately after instillation of the eye drops has been reported in 4.7% of users. Although phototoxicity has not been reported after ophthalmic use. Since the following allergic reactions have been reported after systemic use of Lomefloxacin, they cannot be excluded after topical ophthalmic use: allergic reactions, asthma, dyspnoea, urticaria, erythema, pruritus and hypersensitization.

Drug interaction

In order to avoid reduction of efficacy, no ophthalmic preparation containing heavy metals, such as zinc, should be used during 15 minutes preceding and following application of Lomeflox. Bacteriostatic ophthalmic antibiotics should not be used concomitantly with Lomefloxacin eye drops. Other interactions have not been described to date.

Use in special groups

The drug should only be used when the benefit outweighs the potential risk for the foetus or the infant.

Packing

Lomeflox Sterile Eye Drops: Each plastic dropper bottle contains 5 ml eye drops.

Other Products from
Antibiotic
 
Erythromycin
Erythromycin
Cefixime
Pivmecillinam
Ciprofloxacin
Amoxycillin
Chloramphenicol
Meropenem
Cefuroxime
Ceftriaxone
Azithromycin
Azithromycin
Besifloxacin Hydrochloride
Ceftazidime
Clindamycin
Cefradine
Cefepime
Rifaximin
Lomefloxacin
Lemefloxacin
Amikacin Sulfate
Sparfloxacin
Moxifloxacin
Gentamicin
Levofloxacin
Flucloxacillin
Tobramycin
Gatifloxacin
Cefpodoxime
Ofloxacin

© 2014. Aristopharma Ltd. All rights reserved.
Site by DIGITA iNTERACTIVE

HOME | PRODUCTS | FACILITIES | GLOBAL PRESENCE | NEWS | ABOUT US | CONTACT | CAREER

Bookmark and Share