REJOIN

Glucosamine Sulphate & Chondroitin Sulphate

Description:

Glucosamine and chondroitin are components of the proteoglycans, which are compounds that supply joint cartilage with some of its structural properties and shock-absorbing functions. Glucosamine is a long chain amino acid, which occurs naturally in cartilage and is the major building block of the proteoglycans and is used specifically to produce glycosaminoglycans (GAG's). Chondroitin, like glucosamine, is a mucopolysaccharide found in cartilage and helps to elevate the fluid levels in the synovial fluid in the joints as it binds to collagen.

Composition:

Each film-coated tablet contains Glucosamine sulphate INN 250 mg and Chondroitin sulphate INN 200 mg.

Pharmacology:

Glucosamine, an amino sugar, is the building block for certain glycosaminoglycans. In vitro, it has been shown to stimulate proteoglycan synthesis by human chondrocytes. It also has some innate anti-inflammatory properties, independent of prostaglandin synthesis. Glucosamine is also involved in the formation of nails, tendons, skin, eyes, bones, ligaments and other connective tissues in the body. Glucosamine is absorbed rapidly from the intestine, and transported to the connective tissues. It helps in the restoration of damaged joint tissue in osteoarthritis.

Chondroitin sulphate is a glycosaminoglycan and is a main constituent of proteoglycans. Like glucosamine, it has been shown to stimulate proteoglycan synthesis by human chondrocytes. Chondroitin sulphate also has some innate anti-inflammatory properties.

Indications:

Relief of osteoarthritis. Other recommended uses are for tendonitis and bursitis. It decreases pain and improves mobility in people suffering from osteoarthritis. It has been suggested, by some sources, that it may even prevent or postpone the development of osteoarthritis in certain groups, such as the elderly and the athletes.

Dosage and Administration:

1-2 tablets three times daily.

Contraindications:
Not known.

Precautions:
Patients allergic to sulphates should take care during treatment with this drug.

Use in pregnancy and lactation:

The Arthritis Association recommends taking cautions in the use of glucosamine and chondroitin sulphate during pregnancy & lactation

Side-effects:
Rare cases of nausea, vomiting, diarrhoea have been reported.

Drug Interactions:

There is no interaction of glucosamine with blood pressure medications, non-steroidal anti-inflammatory drugs, and for diabetics on hypoglycaemic agents (but close monitoring of blood sugar levels is recommended).

Chondroitin sulphate may interact with blood thinning medications like heparin.

Storage:

• Store in cool & dry place protected from light

• Keep out of reach of children

Packing:

Box containing  5x10’s tablets in blister pack.