| REUMACAP
SR
Indomethacin
Description:
Indomethacin is a NSAID having antipyretic and
analgesic properties. A great number of pharmacological studies
have proved that Indomethacin has strong anti-inflammatory,
analgesic, and antipyretic properties. Unlike the corticosteriods,
the effect of Indomethacin is not related to the pituitary gland
or the adrenals. Indomethacin is absorbed promptly following
oral administration and peak plasma levels occur within 2 hours.
Approximately two thirds of this amount is excreted in the urine
and the remainder is excreted in the feces. About 90% of a single
dose is excreted in 24-48 hours. In a number of controlled clinical
trials, Indomethacin (Reumacap) has proved to be of great
value in the treatment of rheumatic diseases. It relieves pain,
reduces joints swelling edema and improves joint mobility.
Composition:
Each sustained release capsule contains Indomethacin
BP 75 mg.
Indications:
Rheumatoid arthritis, ankylosing spondylitis,
and osteoarthritis (degenerative joint disease), gout, acute
non-articular rheumatism (bursitis, synovitis, tendinitis).
Dosage and administration:
Rheumatoid arthritis, Ankylosing spondylitis,
and osteoarthritis (degenerative joint disease): The initial
dose is once daily of Reumacap SR capsule. If severe then twice
daily is required. Acute attacks of gout may be controlled with
a dose of 75 mg sustained release capsule twice daily.
Acute non-articular rheumatism (bursitis, synovitis,
tendinitis):
1-2 capsules daily according to the severity
of these cases.
Adverse reactions:
Headaches, usually in the morning and mild vertigo
may occur during the early weeks of therapy. These symptoms
are transient and usually disappear with continued use or by
reduction of the dose. Rare case of mild psychic disturbances
was also reported which subsided after few days of treatment.
Gastrointestinal reactions such as nausea, vomiting,
diarrhoea, epigastric and abdominal pain are often due to large
doses of the drug and disappear when the dose is reduced.
Administration of the capsule immediately after
meals with an antacid if necessary, minimize the frequency and
the severity of these untoward effects.
Precautions:
Reumacap SR capsule should be used with caution
with psychiatric problems, epilepsy or Parkinsonism since the
drug may aggravate these conditions. It is not recommended for
pregnant women, because at the present time clinical studies
are insufficient. Indomethacin is not given normally in neonates
except when used to assist closure of a patent ductus arteriosus.
Contraindications:
Indomethacin is contraindicated in patients with
ulcer, gastritis, active ulcerative colitis, and should be used
with caution in patients with a history of these disorders.
It is also contraindicated in previously hypersensitive patient.
Drug interaction:
It may interact with anticoagulants, lithium,
diuretics, antihypertensive drugs, diflunisal and sulfonylureas.
Storage:
Packing:
Box containing of 5x10's in blister packs. |
