| REUMACAP
Indomethacin
Description:
Reumacap is a preparation of indomethacin.
Indomethacin is a non-steroidal anti-inflammatory drugs having
anti-inflammatory and analgesic effects with showing to some
extent antipyretic effects.
Composition:
Each capsule contains Indomethacin BP 25 mg.
Pharmacology:
Indomethacin is a non-steroidal compound chemically
different from the salicylates, phenylbutazone and the related
derivatives. A great number of pharmacological studies have
proved that indomethacin (Reumacap) has strong anti-inflammatory,
analgesic and antipyretic properties. Unlike the corticosteroids,
the effect of Reumacap is not related to the pituitary
gland or the adrenals. Reumacap is absorbed promptly
following oral administration, and peak plasma levels occur
within 2 hours. Approximately two third of this amount is excreted
in the urine, and the reminder is excreted in the faces. About
90% of a single dose is excreted in 24 to 48 hours. In a number
of controlled clinical trials, Indomethacin (Reumacap)
has proved to be of great value in the treatment of rheumatic
diseases. It relives pain, reduces joint swelling edema and
improves joint mobility.
Indications:
Rheumatoid arthritis, ankylosing spondylitis,
osteoarthritis (degenerative joint disease).
Gout: Acute nonarticular rheumatism such as bursitis,
synovitis, tendinitis.
Dosage:
The dosage is fixed by the physician according
to the response obtained, and to the eventual untoward effects.
To minimize adverse reactions small doses are given initially,
the size of the dose is then gradually increased until an effective
level is reached.
Rheumatoid arthritis, ankylosing spondylitis
and osteoarthritis (degenerative joint disease):
The initial dose is one 25 mg capsule Reumacap
two or three times daily. If the patient dose not respond to
this dose, this is gradually increased by increments of 25 mg
every three or four days, until a satisfactory response is obtained,
or until a daily dose of 150 mg (6 capsules) is reached.
Gout:
Acute attacks of gout may be controlled with
a dose of 50 mg (2 capsules) three times a day. Usually the
attack subsides within three or four days. To prevent relapse
two capsules daily are administered or as directed by the physician.
Acute nonarticular rheumatism (bursitis, synovitis,
tendinitis): 3-6 capsules daily according to the severity of
the case, and the response obtained.
Adverse Reaction:
Headache, usually in the morning and mild vertigo
may occur during the early weeks of therapy. These symptoms
are transient and usually disappear with continued use or by
reduction of the dose. Rare case of mild psychic disturbance
were also reported, which subside after few days of treatment.
Gastrointestinal reactions such as nausea, vomiting diarrhoea,
epigastric and abdominal pain, are often due to large doses
of the drug and disappear when the dose is reduced. Administration
of the capsules immediately after meals with an antacid if necessary,
minimize the frequency and the severity of these untoward effects.
Precautions-Contraindication:
Reumacap capsules should be used with
caution in patients with psychiatric problems, epilepsy or Parkinsonism
since the drug may aggravate these conditions. It is not recommended
for pregnant women, because at the present time clinical studies
are insufficient. Reumacap is contraindicated in patients
with ulcer, gastritis, active ulcerative colitis, and it should
be used with caution in patients with a history of these disorders,
in these cases, administration of indomethacin suppositories
should be preferred. It is also contraindicated in previously
known hypersensitive patient.
Storage:
Packing:
Reumacap capsules: Box 10×10’s in strip.
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