| RHINIL
Cetirizine
Description:
Rhinil (Cetirizine),
a piperazine derivative and carboxylated metabolite of hydroxyzine,
is a potent antihistamine with distinguishing features are:
(1) Exquisite anti-H1 specificity: Rhinil appears unique
in being devoid of action on receptors other than the H1-receptor,
(2) potency: at unit dose Rhinil is the most potent antihistamine
in the skin and lungs & (3) Absence of metabolism. Therefore,
Rhinil is the choice of H1 antagonist for the management
of the immediate allergic reactions.
Rhinil,
a new second generation H1 antagonist, is the only antihistamine
that possesses activity against both the histamine mediated
'early' phase of the allergic reaction and the 'late' phase
response of immediate hypersensitivity characterize by migration
of inflammatory cells to the site of the reaction. It is an
effective and well tolerated treatment of seasonal and perennial
allergic rhinitis and chronic idiopathic urticaria. The nonsedating
antihistamine Rhinil is also effective on the treatment
of allergen-induced asthma. It has no significant anticholinergic
and antiserotonic effects.
Composition:
Rhinil Tablet:
Each film coated tablet contains Cetirizine Dihydrochloride
INN 10 mg.
Rhinil Liquid:
Each 5 ml of liquid contains Cetirizine Dihydrochloride INN
5 mg.
Indications:
Rhinil is
indicated for the prevention and relief of the followings:
• Seasonal allergic
rhinitis
• Perennial allergic
rhinitis
• Allergic rhino-conjuntivitis
• Allergic rhinitis
and concomitant perennial asthma
• Allergen-induced
asthma
• Ragweed-induced
allergic rhinitis
• Hay fever
• Chronic idiopathic
urticaria
• Pruritus and
other cutaneous symptoms and children suffering from atopic
eczema
• Psoriasis.
Dosage &
administration:
Rhinil Tablet:
Adults and children
over 6 years: 1 tablet once daily or 1/2 tablet twice daily.
Children 2-6 years:
1/2 tablet once daily.
Rhinil Liquid:
Adults and children
over 6 years: 2 teaspoonfuls once daily or 1 teaspoonful twice
daily.
Children 2-6 years:
1 teaspoonful once daily or 1/2 teaspoonful twice daily.
Contraindications:
Rhinil is
contraindicated in patients who have shown hypersensitivity
or idiosyncrasy to it or to its parent compound, Hydroxyzine.
Adverse effect:
Rhinil is
well tolerated and associated with fewer adverse effects compared
with first generation antihistamines. Side effects include headache,
dry mouth, dizziness, agitation and gastrointestinal upset.
Rhinil does not produce anticholinergic effects.
Pregnancy and
lactation:
No evidence of
teratogenicity of Rhinil in animals. There is inadequate
information about its safety during pregnancy. It should be
used only if the potential benefit justifies the potential risk
to the foetus. The extent of Rhinil excretion in human
breast milk is unknown but some animal studies have shown excretion
in breast milk. Nursing mothers are advised not to take this
medicine.
Warning:
-
Caution should be taken with concomitant use of sedatives.
-
The drug is not usually administered to neonates.
-
Nursing mothers are advised not to take this medicine.
-
Some dose reduction may be required, if renal function
is impaired.
Precautions:
Patients are advised
not to exceed the recommended dose if driving car or operating
machinery. At therapeutic dose levels, Rhinil does not
show any potentiation of alcohol. However, care should be exercised.
Packing:
Rhinil Tablet:
Box containing 10x10's tablets in blister pack.
Rhinil Liquid:
Bottle containing 60 ml of Rhinil liquid. |
