| SILVADAZIN Cream
Silver Sulfadiazine 1%
Description:
Silvadazin (Silver Sulfadiazine 1% cream) is the silver salt
of N1 (Pyrimidin-2-y1) sulphanilamide. It is used topically
for the prevention & treatment of infection of wounds from
burns. It is effective against Gram-positive & Gram-negative
bacteria including Pseudomonas aeruginosa, yeast & fungi.
It has a bactericidal action in contrast to Sulfadiazine, the
silver salt acts primarily on the cell membrane & cell wall
& its action is not antagonized by p-amino-benzoic acid.
The compound is painless upon application. It has a pleasant
cooling effect to the burnt surface. It is considered by most
authorities to be the drug of choice for the prevention of infection
of burns.
Composition:
Each gram cream contains Silver Sulfadiazine USP 10 mg.
Absorption and Fate:
A little silver is absorbed. Silver is released from the preparation
in concentrations that are selectively toxic to the microorganism.
Up to about 10% of the Sulfadiazine may be absorbed. Concentrations
in blood of 10 to 20 mcg per ml have been reported although
higher concentrations may be achieved when extensive areas of
the body are treated. Silver Sulfadiazine is slowly metabolized
in contact with wound exudates.
Uses and Administration:
Silvadazin is used in conjunction with debridement for the
prevention & treatment of infection, particularly by Pseudomonas
aeruginosa, in severe burns. Silvadazin is usually applied daily
to a thickness of 3to5 mm by a sterile spatula or gloved hand.
Treatment is continued until healing is progressing satisfactorily
or the burn site is ready for skin grafting. Silvadazin has
also been used in other skin conditions such as leg ulcers,
where infection may prevent healing.
Adverse Effects & Precautions:
Local reactions such as burning, itching, rash have been reported
in patients treated with Silver Sulfadiazine. The separation
of eschar may be delayed & fungal invasion of the wound
may occur. Transient leucopenia has occurred although its association
with application of Silver Sulfadiazine has not been consistently
confirmed.
Contraindications:
It should not be used to treat an established infection. It
is also contraindicated to patients hypersensitive to sulphonamides.
Storage:
Store in a cool a dry place (below 250 C) & away from light.
The tube should be tightly closed. Keep out of the reach of
children.
Packing:
Tube containing 25 g/ 250 g cream. |
