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Composition:
Xelix SR Tablet: Each sustained release tablet contains Indapamide USP 1.5 mg.
Pharmacology:
Indapamide is a diuretic antihypertensive. It appears to cause vasodilation, probably by inhibiting the passage of calcium and other ions (sodium, potassium) across membranes. It has an extra-renal antihypertensive action resulting in a decrease in vascular hyperreactivity and a reduction in total peripheral and arteriolar resistance.
Indications:
- Essential hypertension
- Salt and fluid retention associated with congestive heart failure
Dosage & administration:
1 tablet daily, preferably in the morning.
Contraindications:
Thiazides and related diuretics should be avoided in refractory hypokalaemia, hyponatraemia and hypercalcaemia, symptomatic hyperuricaemia, and Addison's disease.
Side effects:
Side effects of Indapamide include headache, anorexia, gastric irritation, nausea, vomiting, constipation, diarrhoea etc.
Precautions:
Monitoring of potassium and uric acid serum levels is recommended, especially in subjects with a predisposition or sensitivity to hypokalemia and in patients with gout. Although no allergic manifestations have been reported during clinical trials, patients with a history of allergy to sulfonamide derivatives should be closely monitored.
Drug interactions:
Other antihypertensive: Indapamide may add to or potentiate the action of other antihypertensive drugs. Norepinephrine: Indapamide, like the thiazides, may decrease arterial responsiveness to norepinephrine. Lithium: In general, diuretics should not be given concomitantly with lithium because they reduce its renal clearance and add a high risk of lithium toxicity.
Use in special groups:
Use in pregnancy:
Pregnancy category B drug: Indapamide is a US FDA pregnancy category B drug. This means that it may be used during pregnancy.
Use in lactation:
It is not known whether Indapamide is excreted in breast milk.
Use in elderly:
Low dose diuretic therapy has been shown to be effective and relatively safe in the management of hypertension in the elderly.
Overdose:
Symptoms of overdosage would be those associated with a diuretic effect like- electrolyte disturbances, hypotension and muscular weakness.
Storage:
Store in a cool & dry place, protect from light. Keep out of the reach of children.
Packing:
Xelix SR Tablet: Each box contains 30's tablets in blister pack.
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